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New advances in artificial blood vessels are woven with collagen and polylactic acid fibers

Time : 2020-10-12 Hits : 9

In the treatment of patients with heart disease, damaged or blocked parts of the cardiovascular system sometimes need to be replaced, either by autologous transplantation or with biocompatible materials. Autologous transplantation requires not only that the patient can provide a healthy replacement part, but also that the replacement will not affect the patient's normal life, so the requirements are relatively high. For many heart disease patients, doctors often use artificial blood vessels to complete the operation.

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Artificial blood vessels are made from a variety of materials and methods. Recently, a team of researchers from NC State and CWRU woveled an artificial blood vessel by combining collagen and polylactic acid fibers.

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What's new about this artificial blood vessel is that:

(1) Collagen components in collagen fibers can increase the adhesion of initial cells by 10 times. After a certain period of culture, the number of cell accumulation and proliferation is 3.2 times higher than that of artificial blood vessels made of PLA fiber alone, which has a rapid endothelialization effect.

(2) Polylactic acid fiber can provide sufficient mechanical strength and structural stability, and play the role of infrastructure, which is conducive to the high-speed production of this artificial blood vessel, so as to achieve industrialization.

(3) The combined braided artificial blood vessels showed excellent rupture strength (1.89±0.43 MPa) and suture maintenance strength (10.86±0.49 N), and the pressure level (3.98± 1.94% / 100 mmHg) was comparable to that of coronary arteries under normal blood pressure (3.8± 0.3% / 100 mmHg), showing good adaptability.

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(4) The circular weft knitting structure is as flexible as a natural coronary artery and can expand and contract.

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This type of artificial vascular disease is not a permanent implant and can provide support for blood vessel repair at the initial stage of implantation, which can eventually be degraded and absorbed by the body. The main problem, which the team is still trying to overcome, is that the vessel has more structural pores that allow blood to flow out.

The team's work is titled "A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the biological performance of Collagen filaments," Published in Materials Science and Engineering: C.

The original link: https://doi.org/10.1016/j.msec.2020.111418

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