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Functional nanofibers can be used to prevent postoperative recurrence and metastasis of breast cancer

Time : 2020-09-21 Hits : 17

In recent years, the incidence of breast cancer has increased, which is a serious threat to women's life and health. Although it can be treated by surgical excision, the long-term prognosis of patients is still unsatisfactory due to the high incidence of postoperative recurrence and metastasis. At present, postoperative adjuvant chemotherapy is mostly used to reduce recurrence and metastasis, but complications and side effects are often accompanied in this process. Therefore, it is urgent to reduce the side effects of adjuvant chemotherapy and improve the poor prognosis of patients.

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In view of this, the research team of Southwest Jiaotong University proposed an implantable hierarchical structure of ultrafine nanofibers, which have the ability to control drug release and show excellent therapeutic effects in local postoperative chemotherapy for breast cancer.

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The nanofibers were prepared by coaxial electrostatic spinning with polylactic acid (PLA) loaded with dithiolam (DSF) and polyethylene glycol (PEG) loaded with DOX·HCl in the chamber. After implantation, DOX·HCl in the lumen was rapidly released from the fibers, eliminating residual tumor cells and preventing local recurrence of the tumor. DSF in the fibrous matrix is sustainably released, preventing tumor cells from invading the surrounding tissue and thereby preventing metastasis.

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Morphological characterization of fibers


The results show that the water evaporation in PEG solution can form a cavity in the electrospinning process, and the cavity volume is large enough to encapsulate DOX · HCl. The volume and spacing of the Chambers can be achieved by changing the molecular weight of PEG, and the size of the Chambers has a great influence on the release rate of DOX · HCl encapsulated in the Chambers.

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Drug release behavior


The researchers used the Maestro in vivo imaging system to monitor the fiber devices' ability to prevent tumor recurrence and metastasis, and to further evaluate the implantable fiber devices' ability to inhibit tumor recurrence and metastasis in vivo. It was found that the tumor volume of the locally implanted device was much smaller than that of the injected tumor, especially when the molecular weight of PEG was 1000, the tumor volume of the injected tumor was less than 1/80 of that of the injected tumor, and most of the tumor cells were in a non-proliferative state

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In vivo analysis of inhibition of tumor recurrence and metastasis

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